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Optimal DNA & Methylation Test
Regular price
£369.00
Sale price
£258.30
Optimal DNA & Methylation Test analyses 110 genes across 46 personalised reports, including core methylation genes such as MTHFR, MTR, MAOA and COMT, alongside key genes involved in diet, fitness and stress tolerance including VDR, FTO, ACE and ADRB2. It reveals how your body processes nutrients, produces energy and responds to stress, ideal if you want to improve energy, focus, recovery and long-term health.
Using a simple at-home cheek swab, this one-time test delivers lifelong genetic insights in a clear, easy-to-understand report. You’ll learn how to eat, supplement and train in a way that actually works for your biology, helping you feel better, perform better and age well.
What's included :
► Explore 46 DNA insights across methylation pathways, nutrition, and lifestyle
► Understand how your genes influence a range of wellness traits including recovery, detoxification and ageing
► Use your results to optimise diet, supplements and daily routines for lifelong balance
► Includes 1:1 consultation to discuss your results
► Simple at home cheek swab test, with results in 10 days
Optimised health. It’s yours to take.
Take your health to the next level, with our advanced DNA screening test
Your DNA contains the blueprint for how your body truly functions. Genetic Rebalance’s Optimal DNA & Methylation Test reveals that blueprint in exceptional detail, pairing advanced methylation mapping with expanded genetic insights into nutrition, sleep, stress response, fitness, and skin health. It is one of the most comprehensive at-home methylation tests available, built to help you understand, optimise, and take control of your unique biology.
Methylation is one of the body’s most important regulatory systems - influencing gene expression, detoxification, energy production, inflammation balance, and cellular repair. When methylation works efficiently, your body performs at its best. When it falters, fatigue, inflammation, poor recovery, and reduced resilience may appear.
Your Optimal DNA & Methylation results show how effectively these cycles are functioning, highlighting pathways such as the Folate Cycle, Methionine Cycle, BH4 Cycle, and Transsulphuration Pathway, while analysing how your genes interact across more than 9,000 genetic markers.
But this test goes far beyond methylation alone. With more than 45 in-depth DNA reports, you’ll discover how your genetics shape your metabolism, nutritional needs, collagen production, recovery capacity, circadian rhythm, and stress resilience - the core systems that influence your healthspan, vitality, and day-to-day performance.
Genetic Rebalance operates with higher standards than traditional DNA kits. We use an accredited laboratory network for faster processing (typically within ten business days).
Every test also includes 1:1 expert support from Certified Biohacker who help translate your genetic findings into clear, actionable steps.
This is precision health made personal - the smarter way to optimise your methylation, elevate your wellbeing, and perform at your genetic best.
There’s more to methylation testing
Methylation Profile Reports
The Genetic Rebalance DNA Methylation Report examines the genetic variants that influence your body's methylation profile capabilities.
It highlights the activity of key methylation genes, such as MTHFR, during five crucial cycles, including the Folate Cycle. Understanding these genetic influences can help you optimise nutrient absorption, DNA repair, detoxification, neurotransmitter production, and more.
Armed with this knowledge, you can make informed choices about your lifestyle and wellness efforts to support your methylation pathways and enhance your overall health and longevity.
What's Included (5 reports)
Folate Cycle (5 genes)
The Folate Cycle converts dietary folate into usable forms for critical bodily processes. Understanding your genetic predispositions is crucial because variations like impaired MTHFR or DHFR function can significantly reduce folate processing efficiency.
Genes: DHFR, MTHFD1, MTHFR (A1298C), MTHFR (C677T)
Methionine Cycle (6 genes)
The Methionine Cycle drives methylation by producing SAMe - vital for gene expression, detox, and brain chemistry. Variants here can raise homocysteine and stall key pathways like BH4 and Transsulphuration. A methylation panel can uncover blocks behind fatigue, poor focus, and hormonal imbalance.
Genes: MTR, MTRR, FUT2, TCN2, PEMT, BHMT
The Transsulphuration Pathway (2 genes)
This pathway clears homocysteine by turning it into cysteine - fuel for glutathione and taurine. Genetic blocks here can impair detox, raise sulphite toxicity, and drive brain fog and burnout. Screening for these variants can reveal why your stress and recovery systems are under strain.
Genes: CBS (C699T), GSS
The BH4 Cycle (4 genes)
The BH4 Cycle makes key neurotransmitters like dopamine and serotonin and supports nitric oxide and thyroid function. It depends on folate and SAMe from other cycles. Variants can lead to mood issues, poor sleep, and low motivation. Knowing your BH4 profile helps explain and address deeper neurological imbalances.
Genes: MTHFR (A1298C), COMT, VDR, MAOA, MAOB
Urea Cycle (2 genes)
The Urea Cycle detoxifies ammonia by converting it into urea for safe excretion - a vital process linked to liver function, nitrogen balance, and brain health. It also produces arginine, needed for nitric oxide (NO), which supports blood flow and protects your heart. Variants here or low BH4 can impair NO production, increasing oxidative stress and cardiovascular risk.
Genes: NOS3, SOD2
Nutrition Reports
The Genetic Rebalance DNA Nutrition Report focuses on the genetic variants that influence micronutrient (vitamins & minerals) and macronutrient (carbs & fats) needs and can help define any sensitivities or intolerances that you may have.
These variants can affect your body's predisposition to coeliac disease or lactose intolerance, as well as its requirements for specific nutrients over and above RDAs.
Armed with this information, you can tailor your meals and general diet to suit your unique needs and optimise your nutrient absorption to feel your best every day.
What's Included (24 reports)
Carbohydrate Sensitivity (9 genes)
Your genes influence how well you process carbs, your insulin sensitivity, and how efficiently you use glucose. Some people are more prone to blood sugar spikes from high-GI foods, increasing the risk of insulin resistance. Knowing your genetic response helps you tailor carb choices to support steady energy, gut health, and long-term metabolic balance.
Genes: ACE, PPARG, TCF7L2, ADRB2, CLOCK, PLIN, INSIG, FTO, FABP2
Saturated Fat Sensitivity (15 genes)
This panel reveals how your body absorbs and processes fat, especially saturated fat, and how it affects your cholesterol levels. While fats are essential for energy, vitamin absorption, and cell health, some genotypes are more sensitive to saturated fat, raising the risk of high cholesterol and heart disease. Knowing your fat response helps you make smarter, heart-healthy choices.
Genes: APOC3, APOA5, APOA2, LPL, FABP2, FTO, CETP, LEPR, MC4R, PLIN, TCF7L2, PPARG, APOE, LIPC, APOE
Vitamin A (2 genes),
Your genes affect how efficiently you convert carotenoids into active vitamin A (retinol), with some people converting up to 60% less. Poor converters need more preformed vitamin A to support vision, immunity, and gene expression. Understanding your genetic efficiency helps ensure you’re meeting your body’s true vitamin A needs.
Genes: BCMO1, BCO1
Vitamin B2 (2 genes), Vitamin B6 (2 genes) and Vitamin B9 (3 genes)
Vitamin B2 (2 genes)
Riboflavin (vitamin B2) powers key coenzymes involved in energy production, fat metabolism, and detoxification. It also supports healthy homocysteine levels, especially in those with MTHFR variants that reduce enzyme efficiency by up to 65%. If you carry these variants, targeted B-vitamin support can help lower cardiovascular risk and optimise methylation. Genes: MTHFR (C677T), MTHFR (A1298C)
Vitamin B6 (2 genes)
Vitamin B6 supports over 140 enzyme reactions, including those involved in brain function, blood vessel health, and antioxidant defence. It also helps lower homocysteine, especially important for those with low-functioning MTHFR variants. For these individuals, B6 can play a key role in reducing cardiovascular risk and supporting optimal methylation. Genes: MTHFR (C677T), NBPF3
Vitamin B9 (3 genes)
Folate is central to one-carbon metabolism, working with B12, B6, and riboflavin to regulate homocysteine and support heart, immune, and brain health. MTHFR variants can reduce folate processing by up to 65%, raising homocysteine and disease risk. Knowing your genetic efficiency helps guide the right form and dose of folate for optimal protection. Genes: MTHFR (C677T), MTHFR (A1298C), CBS
Vitamin C (3 genes)
Vitamin C supports collagen production, hormone synthesis, immunity, and antioxidant defence. But genetic variations in how you absorb and transport vitamin C can leave you with suboptimal levels - even with a good diet. Testing helps identify whether your genes may be limiting this vital nutrient’s impact on your skin, stress response, and long-term health.
Genes: SLC23A1, GSTT1, SOD2
Vitamin B12 (2 genes)
Vitamin B12 powers red blood cell formation, nerve health, and energy production, and plays a vital role in the methylation cycle. Some people have gene variants that reduce B12 absorption and transport, leading to deficiency even with adequate intake. Testing reveals if your genetics are limiting B12 activity and if you need a more bioavailable form or higher intake.
Genes: FUT2, TCN2
Vitamin D (1 gene)
Vitamin D supports bone strength, muscle function, immunity, and insulin signalling. But your genetic makeup can affect how well you activate, transport, and respond to it. Variants in genes like VDR and CYP2R1 may mean you need more vitamin D than others to maintain optimal levels. Understanding your genetic profile helps tailor your intake to match your body’s true needs.
Genes: VDR
Vitamin E (2 genes)
Vitamin E protects cells from oxidative stress, supports brain and heart health, boosts immunity, and may slow cellular aging. However, genetic differences in absorption and transport can lead to lower circulating levels, even with a good diet. Knowing your genetic profile can uncover hidden needs and help you optimise vitamin E’s protective effects.
Genes: CYP4F2, ZPR1
Iron Overload (1 gene) and Iron Deficiency (3 genes)
Iron Overload (1 gene)
Iron is vital for oxygen transport, immune defence, and healthy skin, hair, and nails. But certain genetic variants, especially in the HFE gene, can lead to excessive iron absorption and increase the risk of iron overload (hemochromatosis). Identifying these variants can help you manage iron intake and prevent long-term damage from hidden excess.Genes: HFE
Iron Deficiency (3 genes)
Iron is essential for oxygen transport, immune defence, brain function, and muscle activity. While most focus is on deficiency, some genetic variants – like those in the TMPRSS6 gene – can disrupt how your body regulates iron through hepcidin, affecting absorption and storage. Understanding your genetic control of iron balance helps fine-tune intake and avoid both deficiency and overload.Genes: TMPRSS6, TFR2, TF
Antioxidants (3 genes)
Your antioxidant system defends cells against free radicals, protecting energy levels, thyroid health, immunity, and insulin sensitivity. But genetic differences in key detox enzymes can weaken this defence, raising the risk of chronic diseases. Identifying these variants reveals whether your body needs extra support from diet or lifestyle to boost resilience.
Genes: CAT, GPX1, SOD2
Omega 3 (2 genes)
Omega-3s help lower chronic inflammation and support brain, eye, and nerve health. But your genes affect how well you convert ALA and EPA into DHA – the most active form. If you're a poor converter, you may need more DHA from diet or supplements to meet your body’s needs and boost resilience.
Genes: IL6, TNF
Lactose Intolerance (1 gene)
The LCT gene controls your ability to produce lactase – the enzyme needed to digest lactose in dairy. While most people lose this ability after infancy, some have a genetic trait called lactase persistence, allowing them to tolerate dairy into adulthood. Knowing your LCT status helps you understand whether dairy is a friend or foe to your digestion.
Genes: LCT/MCM6
Coeliac Predisposition (1 gene)
Gluten is a protein found in wheat, barley, and rye but certain HLA gene variants can trigger an immune reaction to it, increasing your risk of Coeliac disease. These genes influence how your immune system responds in the gut. Knowing your HLA status can clarify whether gluten may be harming your health behind the scenes.
Genes: HLA DQ2/DQ8
Fructose Intolerance (1 gene)
Fructose is a natural sugar found in fruit, but variants in the ALDOB gene can impair its metabolism, leading to hereditary fructose intolerance. This can cause nausea, bloating, and discomfort after eating fructose-containing foods. Identifying ALDOB mutations helps explain unexplained digestive symptoms and guides smarter food choices.
Genes: ALDOB
Salt Sensitivity (2 genes)
While the body needs some salt for muscle and fluid balance, certain genetic variants can make you more sensitive to sodium – raising your risk of high blood pressure, heart disease, and stroke. Knowing your salt sensitivity helps you take proactive steps to protect your cardiovascular health.
Genes: ACE, AGT
Alcohol Response (1 gene)
The ADH1C gene influences how your body breaks down alcohol. Some variants produce a slower-acting enzyme, which is linked to higher HDL (“good”) cholesterol levels in moderate drinkers. While this doesn’t affect alcohol tolerance, it can reveal how your genetics shape the impact of alcohol on heart health.
Genes: ADH1C
Caffeine Sensitivity (1 gene)
Your response to caffeine is shaped by your genetics – specifically how quickly your body breaks it down. Fast metabolisers may handle caffeine well, while slow metabolisers are more likely to experience anxiety, sleep issues, and cardiovascular effects. Knowing your caffeine metabolism can help you tailor your intake for better focus, energy, and long-term health.
Genes: CYP1A2
Detoxification Phase I - Toxin Generation Speed (2 genes)
High-heat cooking of meats can produce harmful compounds like HCAs and PAHs, which damage cells through oxidative stress. Your genes influence how efficiently your body detoxifies these compounds. Certain variants may slow this process, increasing your risk of long-term cellular damage. Understanding your genetic detox capacity can guide safer cooking and dietary choices.
Genes: CYP1A2, EPHX1
Detoxification Phase II - Cruciferous Vegetable Needs (2 genes)
Phase II detox relies on enzymes like GSTM1 to neutralise harmful compounds in the liver. Some people carry a deleted version of the GSTM1 gene, meaning this key enzyme is missing – reducing detox capacity. If you have this variant, increasing your intake of cruciferous vegetables can help support your body’s natural detox pathways.
Genes:GSTM1, GSTT1
Sugar Preferences (1 gene)
Excess sugar can lead to fatigue, brain fog, and long-term health issues. A specific genetic variant influences how your body regulates blood glucose and how strongly you crave sweet foods. Carriers of this variant may consume more sugar and face a higher risk of cavities and metabolic imbalances. Knowing your sugar response can help you take control of cravings and protect your health.
Genes: GLUT2
Bitter Taste Perception (1 gene)
Your ability to taste bitterness is influenced by the TAS2R38 gene, which encodes a receptor that detects bitter compounds in foods like broccoli and brussels sprouts. People with certain variants are “supertasters” and may find these foods more intense or unpleasant. Knowing your taste genetics can help explain food preferences – and guide strategies for improving dietary variety.
Genes: TAS2R38
Fitness Reports
The Genetic Rebalance DNA Fitness Report reveals the genetic variants that affect your response to exercise intensity, training type, exercise-related injuries and more.
This comprehensive information serves as the compass guiding your fitness journey: with it, you can ensure that your training regimen is targeted and efficient, leading to optimal results aligned with your specific fitness targets.
Genetics shouldn't be used to determine your fitness goals; your results should be used to ensure you take the most personalised path to achieving them!
What's Included (4 reports)
Training Intensity Response (14 genes)
Your genes play a key role in how you respond to different types of exercise - whether you’re better suited to power-based or endurance-focused training. Matching your workouts to your genetic profile can dramatically boost results, with studies showing up to three times greater improvement when training is aligned to your DNA.
Genes: ADRB2, CRP, COL5A1, TRHR, BDKRB2, IL6, ACTN3, VEGF, PPARA, ACE, AGT, NRF, VDR, PPARGC1A
Aerobic Training Response (4 genes)
VO₂max is a key measure of aerobic fitness, reflecting how efficiently your body uses oxygen during exercise. Genetics play a strong role in your capacity to improve VO₂max with training - some people respond more dramatically than others. Knowing your genetic potential helps tailor your fitness approach and set realistic goals.
Genes: ADRB2, CRP, PPARGC1A, VEGF
Recovery Efficiency (7 genes)
Your recovery rate is influenced by how well your body manages oxidative stress and inflammation after exercise. Genetic variants in key detox and inflammatory genes can slow recovery, making you more prone to fatigue, soreness, and overtraining. Understanding your recovery profile helps optimise rest, reduce injury risk, and get more from every workout.
Genes: SOD2, IL6, IL6R, CRP, TNF, GSTM1, GSTT1
Injury Predisposition (7 genes)
Your genes influence how well your body repairs connective tissue and manages inflammation - two key factors in injury risk. Variants in genes like COL1A1, CRP, and TNF can affect how resilient your joints and tendons are under stress. Knowing your genetic risk helps you train smarter, recover better, and prevent avoidable injuries.
Genes: GDF5, COL1A1, COL5A1, IL6, IL6R, CRP, TNF
Sleep & Stress Reports
Your Genetic Rebalance DNA Sleep and Stress Report delves into the genetic factors influencing your sleep patterns and stress coping mechanisms.
Your results will uncover your genetic tendency towards being a morning lark or a night owl, shedding light on whether you are naturally more productive in the morning or evening. Additionally, this report provides insights into how your genetic makeup impacts your ability to have high quality sleep, or cope with stress effectively.
With this information, you can strategically tailor your daily routines, optimise your sleep schedule, and implement stress management techniques that align with your DNA.
What's Included (5 reports)
Chronotype (9 genes)
Your genetic chronotype shapes your internal body clock - determining when you naturally feel most alert or sleepy. It influences your energy patterns, hormone cycles, and even workout or productivity timing. By analysing multiple genes linked to circadian rhythm, we can identify whether you're more of a morning lark or a night owl, helping you align your lifestyle with your biology.
Genes: RNASEL, VIP, PER3, PER2, RASD1, FBLX3, PLCL1, RGS16, HCRTR2
Sleep Quality (2 genes)
Sleep is essential for mental and physical recovery but how easily you fall and stay asleep can be influenced by your genes. Variants in genes like ADA and MEIS1 affect sleep depth, efficiency, and sensitivity to disturbances. Understanding your genetic sleep profile can help you optimise rest, manage stress, and improve overall wellbeing.
Genes: ADA, MEIS1
Caffeine & Sleep Response (1 gene)
Caffeine keeps you alert by blocking adenosine, the chemical that builds sleep pressure in your brain. But certain variants in the ADORA2A gene can make you more sensitive to caffeine’s effects - leading to disrupted sleep or insomnia, especially if consumed late in the day. Your genetic profile helps determine how caffeine affects your sleep and circadian rhythm.
Genes: ADORA2A
Stress Tolerance (10 genes)
Your body’s response to stress is driven by hormones like cortisol and adrenaline but how you process stress is also shaped by your genes. Variants in key genes can influence dopamine sensitivity, emotional regulation, and how resilient you are under pressure. Understanding your genetic stress profile helps you manage triggers more effectively and build long-term resilience.
Genes: XKR6, MIR2113, BDNF, COMT, DCAF5, FKBP5, HTR2A, LINCOO461, NOS1, OXTR
Warrior or Strategist (1 gene)
The COMT gene influences how quickly your brain clears dopamine during stress, shaping how well you perform under pressure. Fast metabolisers tend to stay calm in high-threat situations, while slow metabolisers may excel in complex, detail-heavy tasks. Your COMT type can help explain your natural stress tolerance and the environments where you thrive best.
Genes: COMT
Skin Reports
The Genetic Rebalance DNA Skin Report delves into the nuanced interplay of genetic factors that shape your skin's distinct characteristics. From its appearance and elasticity to susceptibility to ageing and inflammation, your genes encode a blueprint that influences your skin's individuality.
This report examines how external factors like diet, lifestyle choices and sun exposure interact with your genetic makeup, further influencing your skin's health and resilience.
Empowered by these insights, you can tailor your skincare routine to align with your unique needs, addressing specific concerns and optimising your skin's response to environmental factors.
What's Included (7 reports)
Skin Ageing (4 genes)
Skin ageing is driven by both genetics and environment - with UV exposure accounting for up to 90% of external ageing. Genes involved in collagen, elastin, and skin remodelling influence how well your skin maintains its structure over time. Small genetic variations can accelerate sagging, wrinkles, and loss of elasticity. Knowing your skin-ageing profile helps guide preventative care from the inside out.
Genes: MMP1, MMP3, COL1A1, ELN
Oxidative Stress (3 genes)
UV exposure triggers free radical production in the skin, accelerating ageing and cellular damage. Your body relies on antioxidant enzymes to neutralise these effects but genetic variations in genes like SOD2, CAT, and GPX1 can reduce their efficiency. If your defences are genetically weaker, you may be more susceptible to oxidative stress from sun and pollution.
Genes: SOD2, CAT, GPX1
Sensitivity to Refined Carbohydrate & Glycation (9 genes)
Advanced glycation end products (AGEs) build up when excess sugar reacts with proteins in the body, accelerating ageing and increasing the risk of chronic disease. Your genetic sensitivity to refined carbs - shaped by genes like ACE, PPARG, PLIN, and TCF7L2 - influences how much glucose lingers in your system to drive this damage. Knowing your glycation risk helps you personalise your carb intake to slow cellular ageing.
Genes: ACE, PPARG, TCF7L2, ADRB2, FTO, CLOCK, PLIN, INSIG, FABP2
Pigmentation (2 genes)
Melanin determines your skin, hair, and eye colour - and your natural protection against UV damage. Genetic variants in genes like MC1R and SLC24A5 influence how much melanin you produce and how it’s distributed. Lighter skin tones may be more vulnerable to sun damage but can produce vitamin D more efficiently. Understanding your melanin profile helps balance sun protection with vitamin D needs.
Genes: MC1R, SLC24A5
Nickel Sensitivity (3 genes)
Nickel is a common trigger for contact allergies, often found in jewellery and everyday items. Variants in genes like GSTM1 and GSTT1 can reduce your body’s ability to detoxify allergens, while TNF influences how strongly you react to irritants. Your genetic profile may explain heightened sensitivity and guide ways to reduce exposure and inflammation.
Genes: GSTM1, GSTT1, TNF
Detoxification (3 genes)
Your body detoxifies harmful substances by converting them into water-soluble forms for safe elimination. Variants in detox genes like EPHX1, GSTM1, and GSTT1 can reduce this efficiency, increasing your vulnerability to oxidative stress and toxin build-up. Knowing your genetic detox profile helps you target support through diet, lifestyle, and supplementation.
Genes: EPHX1, GSTM1, GSTT1
Skin Inflammation (2 genes)
Inflammation is your body’s frontline defence against injury, infection, and cell damage but when poorly regulated, it can become chronic and harmful. Variants in genes like IL6 and TNF can heighten inflammatory responses, increasing your risk for accelerated ageing and long-term health issues. Understanding your inflammation profile allows for targeted nutritional and lifestyle strategies to restore balance.
Genes: IL6, TNF
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Why Us ?
Our DNA + Methylation Packages
| Optimal DNA & Methylation | |
|---|---|
| Genes analysed | 110 |
| Methylation Reports | 5 |
| Nutrition Reports | 24 |
| Fitness Reports | 4 |
| Sleep & Stress Reports | 5 |
| Skin Reports | 8 |
| Laboratory testing | In-house, UK lab |
| Turnaround time | 10 business days from sample receipt |
| Expert consultations included | Yes |
| Online results portal | Yes |
| Personalised health recommendations | Yes |
| Price |
|
How it works
Phase 1: Assessment
Choose your report insight level and order your Optimal DNA & Methylation test kit.
🧬 OURDNA AT-HOME TEST
We’ll ship you our easy-to-use home DNA testing kit, for a world of insights with just a simple cheek swab.
Phase 2: Discovery
Return your GRDNA kit using our prepaid return mailer and we’ll analyse your sample at our advanced in-house laboratory.
💉 PRECISION LABORATORY ANALYSIS
We’ll extract your DNA and analyse your sample for over 9000 genetic locations, all within ten working days
📊 GENETIC REPORTS
You'll get over 50 detailed genetic reports including methylation profile.
Phase 3: Action
Once you’ve got your GRDNA results, you’ll unlock a world of personalised health insights with clear support for next steps.
💧 SUPPLEMENTS
Your results will give you guidance on what supplements your body needs.
🩺 1:1 EXPERT CONSULTATION
We are available for free consultations to help reach your goals.
Frequently Asked
Questions
What is the Optimal DNA & Methylation Test?
It’s our most comprehensive analysis, combining methylation insights, nutrigenetics, fitness traits, sleep and stress response, and skin-related genetics to give you a complete view of your biological blueprint.
Why is methylation important for health?
Methylation is a key biological process that influences gene expression, detoxification, energy production, immune balance, neurotransmitter function, and cellular repair.
Genetic variants can affect how efficiently your body uses nutrients like folate and B12, which may impact energy, mood, recovery, and long-term health.
What’s included with the Optimal DNA & Methylation Test?
Your kit includes:
•At-home DNA collection kit + prepaid return
• 5 Methylation reports
• 24 Nutrigenetic reports
• 4 Fitness genetics reports (power/endurance, recovery, training response, injury risk)
• 5 Sleep & stress genetics reports
• 7 Skin health genetics reports
• 1:1 expert support
• Access to your personalised Genetic Rebalance results platform
Which methylation pathways are analysed?
The test covers all major methylation systems, including:
- Folate Cycle
- Methionine Cycle
- Transsulphuration Pathway
- BH4 Cycle
- Urea Cycle
Which methylation genes are included?
We analyse a broad panel of methylation-related genes within a 9,000+ marker analysis, including:
MTHFR, MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2, VDR, and more.
How does the Optimal Test differ from the Advanced Test?
The Optimal Test includes everything in the Advanced Test, plus additional insights into fitness performance, recovery capacity, sleep patterns, stress resilience, and skin ageing and inflammation.
How can this test help improve my health?
You’ll receive precise, personalised recommendations across:
- Nutrition & supplements
- Training & recovery
- Sleep optimisation
- Stress resilience
- Skin health and ageing
These insights help you understand your unique biology and make targeted changes.
What type of support do I receive?
Every test includes 1:1 guidance from our qualified practitioners who help you understand your results and create a practical, personalised action plan.
How long do results take?
Results are usually delivered within 10 business days after your sample reaches our laboratory.
Where is the test available?
We ship globally from the UK, covering most regions worldwide. Shipping times and customs fees vary by location. If your country is not listed at checkout, contact our support team.