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At-home DNA test · Accredited UK lab
Optimal DNA & Methylation Test
The Optimal DNA and Methylation Test analyses 110 genes across 45 personalised reports, including core methylation genes such as MTHFR, MTR, MAOA and COMT, alongside key genes involved in diet, fitness and stress tolerance including VDR, FTO, ACE and ADRB2. It reveals how your body processes nutrients, produces energy and responds to stress, ideal if you want to improve energy, focus, recovery and long-term wellbeing.
Using a simple at-home cheek swab, this one-time test delivers lifelong genetic insights in a clear, easy-to-understand report. You’ll learn how to eat, supplement and train in a way that actually works for your biology, helping you feel better, perform better and age well.
What's included:
► Explore 45 DNA insights across methylation pathways, nutrition, and lifestyle
► Understand how your genes influence a range of wellness traits including recovery, detoxification and ageing
► Use your results to optimise diet, supplements and daily routines for lifelong balance
► Includes a free 15-minute discovery call with our founder
► Simple at home cheek swab test, with results in 10 days
📄 See a sample of your results: real example pages from a report and how to read them (free PDF).
Sale price
£295.00
Regular price
£369.00
Save 20%
Why buy from us?
Radmila, founder · read our story
- A free 1:1 call before your results, so we know your goals
- Your personal summary: what your results mean for you, reviewed with a specialist nutritionist
- Honest advice, nothing to sell you. We don’t sell supplements
- We’ve been there. Standard tests said “normal”. DNA testing and in-depth blood analysis showed our founder what her body needed.
★★★★★
“The analysis of my DNA was incredibly deep but easy to understand. It didn’t just give me data; it gave me answers.”
Michael
Accredited UK lab
Free UK delivery and prepaid return
45 reports + a personal summary
How it works
Order your kit
Posted to you within 48 hours, with free UK delivery.
Cheek swab at home
Post it back in the prepaid envelope. Your sample is analysed at an accredited UK lab across 9,000+ genetic markers.
Free 15-minute call
While the lab works on your sample, tell us what you want to improve, so your summary focuses on it. Optional.
Your results + summary
45 reports in about 10 working days, plus a personal summary of what matters most for you. Want the full plan? Book a Blueprint session.
Optimised you. It’s yours to take.
Take your performance to the next level, with our advanced DNA test
Your DNA contains the blueprint for how your body truly functions. Genetic Rebalance’s Optimal DNA & Methylation Test reveals that blueprint in detail, pairing advanced methylation mapping with insights into nutrition, sleep, stress response, fitness and skin.
Every sample is analysed at an accredited UK laboratory, and every test includes 1:1 support from a certified biohacker to turn your results into clear, practical steps.
There’s more to methylation testing
45 reports across five areas. Here’s what your results look like.
Methylation Profile
5 reportsKey methylation genes such as MTHFR across five cycles, including the Folate, Methionine and BH4 cycles.
What’s included
Folate Cycle
The Folate Cycle converts dietary folate into usable forms for critical bodily processes. Variations like impaired MTHFR or DHFR function can significantly reduce folate processing efficiency.
Genes: DHFR, MTHFD1, MTHFR (A1298C), MTHFR (C677T)
Methionine Cycle
The Methionine Cycle drives methylation by producing SAMe, vital for gene expression, detox and brain chemistry. Variants here can raise homocysteine and stall key pathways like BH4 and Transsulphuration.
Genes: MTR, MTRR, FUT2, TCN2, PEMT, BHMT
Transsulphuration Pathway
This pathway clears homocysteine by turning it into cysteine, fuel for glutathione and taurine. Variants can affect how efficiently it runs, including how your body handles sulphites.
Genes: CBS (C699T), GSS
BH4 Cycle
The BH4 Cycle makes key neurotransmitters like dopamine and serotonin and supports nitric oxide production. Knowing your BH4 profile can help you support mood, sleep and motivation.
Genes: MTHFR (A1298C), COMT, VDR, MAOA, MAOB
Urea Cycle
The Urea Cycle detoxifies ammonia and produces arginine, needed for nitric oxide, which supports healthy blood flow. Variants can influence nitric oxide production and how your body handles oxidative stress.
Genes: NOS3, SOD2
Nutrition
24 reportsVitamin and mineral needs, carbs and fats, and how your body responds to gluten, lactose, caffeine and more.
What’s included
Carbohydrate Sensitivity
How well you process carbs, your insulin sensitivity and how efficiently you use glucose, so you can choose carbs that support steady energy.
Genes: ACE, PPARG, TCF7L2, ADRB2, CLOCK, PLIN, INSIG, FTO, FABP2
Saturated Fat Sensitivity
How your body absorbs and processes fat, especially saturated fat, and how it affects your cholesterol levels.
Genes: APOC3, APOA5, APOA2, LPL, FABP2, FTO, CETP, LEPR, MC4R, PLIN, TCF7L2, PPARG, APOE, LIPC
Vitamin A
How efficiently you convert carotenoids into active vitamin A. Poor converters may need more preformed vitamin A.
Genes: BCMO1, BCO1
Vitamins B2, B6 and B9
How your genes affect riboflavin, B6 and folate needs, which work together to support methylation and healthy homocysteine levels.
Genes: MTHFR (C677T), MTHFR (A1298C), NBPF3, CBS
Vitamin C
How you absorb and transport vitamin C, which supports collagen, immunity and antioxidant defence.
Genes: SLC23A1, GSTT1, SOD2
Vitamin B12
Whether your genes may limit B12 absorption and transport, and whether a more bioavailable form could suit you.
Genes: FUT2, TCN2
Vitamin D
How well you activate, transport and respond to vitamin D, so you can tailor your intake.
Genes: VDR
Vitamin E
Genetic differences in absorption and transport that can lead to lower vitamin E levels, even with a good diet.
Genes: CYP4F2, ZPR1
Iron Absorption
Variants linked to higher iron absorption, or to how your body regulates iron storage, to help fine-tune your intake.
Genes: HFE, TMPRSS6, TFR2, TF
Antioxidants
How efficient your key antioxidant enzymes are, and whether extra support from diet or lifestyle could help.
Genes: CAT, GPX1, SOD2
Omega 3
How well you convert ALA and EPA into DHA, the most active form.
Genes: IL6, TNF
Lactose Intolerance
Whether you carry the trait that lets you digest lactose into adulthood.
Genes: LCT/MCM6
Coeliac Predisposition
Whether you carry HLA variants linked to how the immune system responds to gluten, which you can discuss with your GP.
Genes: HLA DQ2/DQ8
Fructose Intolerance
How your body processes fructose, the natural sugar in fruit.
Genes: ALDOB
Salt Sensitivity
Whether you may be more sensitive to sodium, which can affect blood pressure.
Genes: ACE, AGT
Alcohol Response
How your genetics shape the way your body processes alcohol.
Genes: ADH1C
Caffeine Sensitivity
Whether you are a fast or slow caffeine metaboliser.
Genes: CYP1A2
Detoxification Phase I
How efficiently your body handles compounds from high-heat cooking, to guide cooking and diet choices.
Genes: CYP1A2, EPHX1
Detoxification Phase II
Whether you may benefit from more cruciferous vegetables to support natural detox pathways.
Genes: GSTM1, GSTT1
Sugar Preferences
How your genes influence blood glucose regulation and sweet cravings.
Genes: GLUT2
Bitter Taste Perception
Whether you are a “supertaster”, which can explain food preferences.
Genes: TAS2R38
Fitness
4 reportsPower or endurance, recovery, training response and injury tendencies.
What’s included
Training Intensity Response
Whether you are better suited to power-based or endurance-focused training.
Genes: ADRB2, CRP, COL5A1, TRHR, BDKRB2, IL6, ACTN3, VEGF, PPARA, ACE, AGT, NRF, VDR, PPARGC1A
Aerobic Training Response
Your genetic capacity to improve VO₂max with training, so you can set realistic goals.
Genes: ADRB2, CRP, PPARGC1A, VEGF
Recovery Efficiency
How your body manages oxidative stress and inflammation after exercise, to optimise rest and recovery.
Genes: SOD2, IL6, IL6R, CRP, TNF, GSTM1, GSTT1
Injury Predisposition
How well your body repairs connective tissue and manages inflammation, to help you train smarter.
Genes: GDF5, COL1A1, COL5A1, IL6, IL6R, CRP, TNF
Sleep & Stress
5 reportsMorning lark or night owl, caffeine and sleep, and how you cope with stress.
What’s included
Chronotype
Whether you are more of a morning lark or a night owl, so you can align your routine with your body clock.
Genes: RNASEL, VIP, PER3, PER2, RASD1, FBLX3, PLCL1, RGS16, HCRTR2
Sleep Quality
How your genes affect sleep depth, efficiency and sensitivity to disturbances.
Genes: ADA, MEIS1
Caffeine & Sleep Response
How sensitive your sleep may be to caffeine, especially later in the day.
Genes: ADORA2A
Stress Tolerance
How your genes influence dopamine sensitivity, emotional regulation and resilience under pressure.
Genes: XKR6, MIR2113, BDNF, COMT, DCAF5, FKBP5, HTR2A, LINC00461, NOS1, OXTR
Warrior or Strategist
How quickly your brain clears dopamine during stress, and the environments where you thrive.
Genes: COMT
Skin
7 reportsSkin ageing, sun response, glycation, sensitivity and more.
What’s included
Skin Ageing
Genes involved in collagen, elastin and skin remodelling, to guide preventative care.
Genes: MMP1, MMP3, COL1A1, ELN
Oxidative Stress
How well your antioxidant defences handle free radicals from sun and pollution.
Genes: SOD2, CAT, GPX1
Refined Carbohydrate & Glycation
Your sensitivity to refined carbs, which can drive glycation linked to skin ageing.
Genes: ACE, PPARG, TCF7L2, ADRB2, FTO, CLOCK, PLIN, INSIG, FABP2
Pigmentation
How your genes influence melanin, to balance sun protection with vitamin D needs.
Genes: MC1R, SLC24A5
Nickel Sensitivity
Genetic factors that may explain heightened sensitivity to nickel.
Genes: GSTM1, GSTT1, TNF
Detoxification
How efficiently your body clears harmful substances, to target support through diet and lifestyle.
Genes: EPHX1, GSTM1, GSTT1
Skin Inflammation
How your genes influence inflammatory responses in the skin.
Genes: IL6, TNF
Real reviews from customers
★★★★★
A literal game changer
“I went into this looking for a DNA test, but what I received was a complete blueprint for a better life.”
Michael F
★★★★★
I highly recommend Genetic Rebalance
“What impressed me most was how personalised the recommendations were.”
Sam Tilley
★★★★★
Good experience
“I did the test myself and was genuinely impressed by how straightforward the process was.”
Vania Koseva
Why us?
Deeper analysis
Many methylation tests look at a small set of variants. Ours analyses over 9,000 genetic markers across 110 genes, for a detailed picture of how your body works.
Data security
Your genetic information is protected at every stage, with encryption and strict access controls.
Fast turnaround
Analysed at an accredited UK laboratory, with results in about 10 working days.
What you get
| Optimal DNA & Methylation | £295.00 |
|---|---|
| Genes analysed | 110 |
| Methylation reports | 5 |
| Nutrition reports | 24 |
| Fitness reports | 4 |
| Sleep & stress reports | 5 |
| Skin reports | 7 |
| Laboratory | Accredited UK lab |
| Turnaround | ~10 working days |
| Free 15-minute discovery call | Included |
| Personal results summary | Included |
Frequently asked questions
What is the Optimal DNA & Methylation Test?
It’s our most comprehensive analysis, combining methylation insights, nutrigenetics, fitness traits, sleep and stress response, and skin-related genetics to give you a complete view of your biological blueprint.
Why does methylation matter?
Methylation is a key biological process that influences gene expression, detoxification, energy production, immune balance, neurotransmitter function, and cellular repair.
Genetic variants can affect how efficiently your body uses nutrients like folate and B12, which may impact energy, mood, recovery, and long-term wellbeing.
What’s included with the Optimal DNA & Methylation Test?
Your kit includes:
• At-home DNA collection kit + prepaid return
• 5 Methylation reports
• 24 Nutrigenetic reports
• 4 Fitness genetics reports (power/endurance, recovery, training response, injury risk)
• 5 Sleep & stress genetics reports
• 7 Skin genetics reports
• 1:1 expert support
• Your personal results summary
Which methylation pathways are analysed?
Methylation is a process your body runs all the time to turn food into energy, clear out waste and make the chemicals that affect your mood. The test looks at five parts of it:
- Folate cycle: how well your body uses folate (vitamin B9) from foods like leafy greens
- Methionine cycle: how you use vitamin B12 and other nutrients to keep the whole process running
- Transsulphuration pathway: how your body clears waste and makes glutathione, its main antioxidant
- BH4 cycle: how you make serotonin and dopamine, the chemicals behind mood, focus and sleep
- Urea cycle: how your body clears ammonia and supports healthy blood flow
In short, it shows which nutrients your body may need more of, so you can choose the right foods and supplement forms for you.
Which methylation genes are included?
We analyse a broad panel of methylation-related genes within a 9,000+ marker analysis, including:
MTHFR, MTR, MTRR, COMT, BHMT, CBS, MAOA, MAOB, DHFR, FUT2, NOS3, PEMT, SOD2, TCN2, VDR, and more.
How are the genes in the test chosen?
Your test looks at SNPs: small, common differences in your DNA that influence how your body uses nutrients, handles stress, recovers from exercise and more. Your sample is analysed on a custom Illumina DNA microarray in an accredited UK laboratory, covering 110 genes and over 9,000 genetic markers. A variant is only included in your report if its effect has been shown in human studies and replicated in at least three separate research studies, so your results focus on findings with solid evidence behind them.
How can this test help me?
You’ll receive precise, personalised recommendations across:
- Nutrition & supplements
- Training & recovery
- Sleep optimisation
- Stress resilience
- Skin and ageing
These insights help you understand your unique biology and make targeted changes.
Is this an epigenetic or "biological age" test?
No. This test looks at the genes you were born with, including key methylation genes such as MTHFR, COMT and MTR, to show how efficiently your methylation pathways are likely to work. Because your genes don't change, you only need to take it once. Epigenetic or "biological age" tests measure something different: chemical marks on your DNA that change over time with lifestyle, and they are usually repeated to track progress. Our test is designed to guide your nutrition, supplement and lifestyle choices for life.
What type of support do I receive?
Every test includes a free 1:1 call with the founder, a certified biohacker, plus a personal summary of your results, reviewed with a specialist nutritionist. If you work with a personal trainer, your summary can be shared with them too.
How long do results take?
Results are usually delivered within 10 business days after your sample reaches our laboratory.
Where is the test available?
We ship to the UK and selected European countries. You'll see the full list at checkout. If your country isn't listed, please get in touch.
Genetic Rebalance provides wellness and lifestyle guidance. It is not a medical service and does not diagnose, treat or cure any condition. If you have a health concern, please speak to your GP.